רוכלין

לפרטים על תואר ראשון ושני

למידע נוסף על לימודים אקדמיים בלבד השאירו פרטיכם ונחזור בהקדם

ראשי » רוכלין
ד''ר רוכלין אלימלך,
מרצה
  • בתיאום מראש

Curriculum Vitae
קורות חיים

Education

השכלה

 

Ph.D (ד"ר לפילוסופיה, כימיה אורגנית), האוניברסיטה העברית, ירושלים, 2002.

M.Sc תואר שני בכימיה,אוניברסיטת סנט פטרבורג, 1980.

 

Work Experience

ניסיון עבודה

 

 

1988 – 1994 Department of Organic Chemistry, Hebrew University, Jerusalem, Israel

1994 – 2004 Researcher / Senior Scientist/ Chief Chemist, Lipiderm Ltd., Jerusalem, Israel

2004 – 2005 Postdoctoral fellow , Dept. of Bone Marrow Transplantation in Hadassah Hospital and Dept. of Organic Chemistry in Hebrew University, Jerusalem, Israel

2005 – 2012 Chief Chemist, NasVax Ltd., Ness Zionna, Israel

2002 - Lecturer, Department of Bioinformatics,Jerusalem College of Technology, Israel

 

Publications

פרסומים

  1. Substituted xanthenylidene enols. The importance of -Ar-C=C conjugation in stabilization of aryl-substituted enols. Elimelech Rochlin and Zvi Rappoport, J. Am. Chem. Soc. 114, 230-241 (1992).
     
  2. The effect of tetra-m-bromo and tetra-m-methyl buttressing on the ground state structures, rotational barriers and keto-enol equilibria of 2,2-dimesityl-1-R (and 1-H) ethenols Irina Eventova, Ella B. Nadler, Elimelech Rochlin, Joseph Frey and Zvi Rappoport,     J. Am. Chem. Soc., 115, 1290-1302 (1993).
     
  3. Mapping the enantiomerizattion routes of triarylvinyl propellers. Barriers for the 3-ring flip and the three different 2-ring flips of m-methoxy-substituted trimesityvinyl isopropyl ethers. Elimelech Rochlin and Zvi Rappoport J. Org Chem. 59, 3857-3870 (1994).
     
  4. Recent advances in the chemistry of stable simple enols. Zvi Rappoport, Joseph Frey, Mark Sigalov and Elimelech
    Rochlin. Pure Appl. Chem., 69, 1933-1940 (1997).
     
  5. Stable simple enols.  Resolution of chiral 1-[9’-(2’-fluoroanthryl)]-2,2-dimesitylethenol. A different racemization mechanism for the enol and its acetate. Elimelech Rochlin and Zvi Rappoport. J. Org. Chem., 68, 216-226 (2003).
     
  6. Stable simple enols. Self-catalyzed E/Z isomerization of the sterically crowded 2-(m-methoxymesityl)-1,2-dimesitylethenol. Elimelech Rochlin and Zvi Rappoport.    J. Org. Chem., 68, 1715-1720 (2003).
     
  7. Process for large scale preparation of sphingosines and ceramides.  Elimelech Rochlin.  United States Patent 6,469,148 October 22, 2002
     
  8. SPHINGOLIPIDS' POLYALKYLAMINES CONJUGATES, Barenholtz Y., Simberg D., Rochlin E., WO2004/110980, 23.12.2004
     
  9. Sphingomyelin, intermediates thereof and methods for preparation of same E. Rochlin, J. Hildesheim, A. Berlin, WO2005/068480 July 28, 2005
     
  10. Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine. Even-Or O., Samira S., Rochlin E., Balasingam S., Mann A.J., Lambkin-Williams R., Spira J., Goldwaser I., Ellis R., Barenholz Y., Vaccine, 28 (39), 6527-6541,(2010)
     
  11.  A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity. Orli Even-Or, Aviva Joseph, Noga Itskovitz-Cooper, Sarit Samira, Eli Rochlin, Hagit Eliyahu, Itzik Goldwaser, Shobana Balasingam, Alex J. Mann, Rob Lambkin-Williams, Eli Kedar, Yechezkel Barenholz., Vaccine, 29 (13), 2474-  2486,(2011)

 

Papers presented at Conferences

 

1.         Recent advances in the chemistry of crowded aryl-substituted enols.

Zvi Rappoport, Ella Nadler, Irena Eventova and Elimelech Rochlin,  Frontiers in Chemistry, 2nd TUB-Hebrew University Conference, Jerusalem, March 18-22, 1990, Abstr. p. 82

2.         Spontaneous enolization of 9-formyl and 9-aroyl xanthenes. The importance of -C=C conjugation in stabilization of triarylethenols.

 Elimelech Rochlin and Zvi Rappoport,  10th IUPAC Conference on Physical Organic Chemistry, Haifa, August 5-10, 1990, Abst. A13, p. 27.

3.         Buttressing, isomerization and rotational barriers for several stable enols and derivatives.

Zvi Rappoport, Irina Eventova, Elimelech Rochlin and Joseph Frey,  Toronto International Conference on Organic Reactive Intermediates (TICORI), Scarborough College, Toronto, July 30-August 1, 1992. Abstr.

4.         Recent studies of intramolecular rotations of di- and tri-arylvinyl propellers.

Zvi Rappoport, Elimelech Rochlin, Joseph Frey and Etti Schottland. The 52nd Meeting of the Israel Chemical Society, Ramat-Gan, 17-18 February 1993, Abs. p. 41 (No page numbers in book).

5.         Intramolecular rotations in substituted trimesitylvinyl propellers.

Z. Rappoport and E. Rochlin, 8th European Symposium on Organic Chemistry, Sitges, Spain, August 29 - September 3, 1993, Abstr. OCB-4.

6.         E-Z Isomerization of crowded triarylethenols.

Elimelech Rochlin and Zvi Rappoport,  59th Meeting of the Israel Chemical Society, Beer Sheva, January 31-February 1, 1994, Abstract, p. 183.

7.         Improved vaccines against influenza and other pathogens based on adjuvantation and delivery with a novel polycationic sphingolipid – CCS: Immunogenicity and efficacy studies in animal models

Samira S., Joseph A., Goldwaser I., Rochlin E., Flasterstein O., Spira J., Barenholz Y. and Kedar E., The 2nd International Conference on Influenza Vaccines for the World, IVW 2006, Vienna, Austria, 18-20 October 2006,