סנדרוביץ'

לפרטים על תואר ראשון ושני

למידע נוסף על לימודים אקדמיים בלבד השאירו פרטיכם ונחזור בהקדם

ראשי » סנדרוביץ'
פרופ' סנדרוביץ' חנן,
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  • בתיאום מראש

Curriculum Vitae
קורות חיים

EDUCATION

1984 - 1987:           B.Sc., Chemistry, Tel Aviv University, Tel Aviv, Israel

1987 - 1993:           Ph.D., Computational Organic Chemistry,
                                Tel Aviv University, Tel Aviv, Israel, Laboratory of  Professor Benzion Fuchs
                                Ph.D. title: " Studies in Stereoelectronics: Theory vs. Experiment"

1993 - 1994:           Post Doctorate Fulbright Fellow,
                                Department of Chemistry, Columbia University, New York, USA,
                                Laboratory of Professor Clark Still

1994 - 1997:           Post Doctorate Research Scientist,
                                Department of Chemistry, Columbia University, New York, USA,
                                Laboratory of Professor Clark Still

 

POSITIONS AND EMPLOYMENT

1991:                          Visiting Research Fellow, Heidelberg University, Heidelberg, Germany

1997 - 2003:               Molecular Modeller and Head of Molecular Modeling Unit, Peptor Ltd., Ness Ziona, Israel

2003 - 2008:               Executive Director Computational Development, EPIX Pharmaceuticals, Ramat Gan, Israel

2009 - Present:          Lecturer at Machon Tal, Jerusalem College of Technology, Jerusalem, Israel.

2009 - Present:          Associate Professor, Department of Chemistry, Bar Ilan University

 

 

ACADEMIC ACTIVITIES

1995:                          Faculty member at the 5th European Workshop in Drug Design, Siena, Italy

1997:                          Faculty member at the 6th European Workshop in Drug Design, Siena, Italy

2008 - Present:          Member of the board of directors of the Israeli Society for Bioinformatics and Computational Biology

2008 - 2009:               Advisor to CFFT (Cystic Fibrosis Foundation Therapeutic)

2009 - Present:          Member of the CFTR 3D consortium organized by CFFT

2010:                          Head of the organizing committee of the 8th conference of the Israeli           Association of Medicinal Chemistry

2011:                          Member of the organizing committee of the 76th conference of the Israel Chemical Society

2011:                          Faculty member at the 8th European Workshop in Drug Design, Siena, Italy

2013:                          Faculty member at the 9th European Workshop in Drug Design, Siena, Italy

 

 

AWARDS AND FELLOSHIPS

1985 - 1987:               Dean's list, undergraduate

1988:                          Dean's list, graduate

1991:                          D. Ben-Gurion Research Fund

1993:                          The Israel Chemical Society's Excellence Award for Graduate Students

1993 - 1994:               The Fulbright Junior Researcher Fellowship

 

RESEARCH INTERESTS

Computational chemistry and biology, Molecular Modeling, Computer Aided Drug Design, QSAR, QSPR, Chemoinformatics

 

PUBLICATIONS

  1. Lecka, J.; Ben-Daviv, G.; Simhaev, L.; Eliahu, S.; Oscar, J.; Luyindula, P.; Pelletier, J.; Fischer, B.; Senderowitz, H.; Sevigny, Non-Hydrolysable ATP Analogs as Selective Inhibitors of Human NPP1:  A Combined Computational / Experimental Study J. Med. Chem. Submitted for publication
     
  2. Gilad, Y.; Senderowitz, H. Docking Studies on DNA Intercelators J. Chem. Inf. Model. Submitted for publication
     
  3. Meltzer-Mats, E.; Babai-Shani, G.; Pasternak, L.; Uritsky, N.; Getter, T.; Viskind, O.; Eckel, J.; Cerasi, E.; Senderowitz, H.; Sasson, S.; Gruzman, A. Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives. J. Med. Chem. 2013, Epub, ahead of print.
     
  4. Hudson, R.; Chong, A.; Protasevich, I.I, Vernon, R.; Noy, E.; Bihler, H.; Li An, J.; Kalid, O.; Sela-Culang, I.; Mense, M.; Senderowitz, H.; Brouillette, C,; Forman-Kay, J.D. Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of CFTR J Biol Chem. 2012, 287, 28480-94.
     
  5. Noy, E.; Senderowitz, H. Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators ChemMedChem 2011, 6, 243-51
     
  6. Noy, E.; Senderowitz, H. Molecular simulations for the evaluation of binding free energies in lead optimization Drug Development Research, 2011, 72, 36-44
     
  7. Stempler, S.; Levy-Sakin, M.; Frydman-Marom, A.; Amir, Y.; Scherzer-Attali, R.; Buzhansky, L.; Gazit E.; Senderowitz, H. Quantitative Structure-Activity Relationship Analysis of β-Amyloid Aggregation Inhibitors J. Comput. Aided. Mol. Design 2011, 25, 135-44
     
  8. Musafia, B.; Senderowitz, H. Biasing conformational ensembles toward bioactive-like conformers for ligand-based drug design Expert Opinion on Drug Discovery, 2010, 5, 943-59
     
  9. Thibodeau, P.H.; Richardson III, J.M.; Wang, W.; Millen, L.; Watson, J.; Mendoza, J.; Du, K.; Fischman, S.; Senderowitz, H.; Lukacs, G.; Kirk, K.; Thomas, P.J. Intragenic suppression of CFTR DF508 facilitates domain-domain association during CFTR biogenesis JBC, 2010 285, 35825-35.
     
  10. Kalid, O.; Fischman, S.; Mense, M.; Shitrit, A.; Bihler, H.; Ben-Zeev, E.; Schutz, N.; Pedemonte, N.; Thomas, P.J.; Bridges, R.J.; Wetmore, D.R.; Marantz, Y.; Senderowitz, H. Structure-Based Discovery of DF508 CFTR Folding Correctors J. Comput. Aided. Mol. Design, 2010, 24, 971-91
     
  11. Sela, I.; Golan, G.; Strajbl, M.; Rivenzon-Segal, D.; Bar-Haim, S.; Bloch, I.; Inbal, B.; Shitrit, A.; Ben-Zeev, E.; Fichman, M.; Markus, Y.; Marantz, Y.; Senderowitz, H.; Kalid, O. G protein coupled receptors -in silico drug discovery and design. Curr Top Med Chem. 2010, 10, 638-56
     
  12. Musafia, B.; Senderowitz, H. A Bioactive conformational biasing: A new method for focusing conformational ensembles on bioactive conformers J. Chem. Inf. Model. 2009, 49, 2469-80
     
  13. Senderowitz, H.; Marantz Y. G protein-coupled receptors: Target-based in silico screening Current Pharmaceutical Design, 2009, 15, 4049-68.
     
  14. Bar-Haim, S.; Aharon, A.; Ben-Moshe, T.; Marantz, Y.; Senderowitz, H. SeleX-CS: A new consensus scoring algorithm for hit discovery and lead optimization J. Chem. Inf. Model., 2009, 49, 623-33
     
  15. Litman, P.; Ohne, O.; Ben-Yaakov, S.; Shemesh-Darvis, L.; Yechezkel, T.; Salitra, Y.; Rubnov, S.; Cohen, I.; Senderowitz, H.; Kidron, D.; Livnah, O.; Levitzki, A.; Livnah, N. A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway Biochemistry, 2007, 46, 4716-4724
     
  16. Hess, S.; Ovadia, O.; Shalev, D.E.; Senderowitz, H.; Qadri, B.; Yechezkel, T.; Salitra, Y.; Sheynis, T.; Jelinek, R.; Gilon, H.; Hoffman, A. Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability J. Med. Chem., 2007, 50, 6201-6211
     
  17. Rayan, A.; Senderowitz, H.; Goldblum, A. Exploring the conformational space of cyclic peptides by a stochastic
    search method J. Mol. Graph. Model., 2004, 22, 319-333
     
  18. Akavia, A.; Senderowitz, H.; Lerner, A.; Shamir, R. Designing multi route synthesis in combinatorial chemistry J. Comb. Chem., 2004, 6, 540-548
     
  19. Falb, E.; Salitra, Y.; Yechezkel, T.; Bracha, M.; Litman, P.; Olender, R.; Rosenfeld, R.; Senderowitz, H.; Jiang, S.; Goodman, M. A Bicyclic and Hsst2 selective somatostatin analog: Design, synthesis conformational analysis and binding Bioorganic & Medicinal Chemistry, 2001, 9, 3255-3264
     
  20. Perez S.; Imberty, A.; Engelsen, S.B.; Gruza, J.; Mazeau, K.; Jimenez-Barbero, J.; Poveda, A.; Espinosa, J.; van Eyck, B.P.; Johnson, G.; French, A.D.; Kouwijzer, M.L.C.E.; Rootenius, P.D.J.; Bernardi, A.; Raimondi, L.; Senderowitz, H.; Durier, V.; Vergoten, G.; Rasmussen, K.  A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrate Carbohydrate Res., 1998, 314, 141-155
  21. Senderowitz, H.; Still, W.C. Sampling the potential energy surface of a Glycyl-Glycine peptide: Comparison of Metropolis Monte Carlo and stochastic dynamics J. Comput. Chem., 1998, 19, 1294-1299
     
  22. Senderowitz, H; Still, W.C. MC(JBW): Simple but smart Monte Carlo algorithm for free energy simulations of  multiconformational molecules J. Comput. Chem., 1998, 19, 1736-1745
     
  23. Senderowitz, H.; McDonald, D.Q.; Still W.C. A practical method for calculating relative free energies of binding. Chiral recognition of peptidic ammonium ions by synthetic ionophores J. Org. Chem., 1997, 62, 9123-9127
     
  24. Diedrich, M.K.; Klärner, F-G.; Beno, B.R.; Houk, K.N.; Senderowitz, H.; Still, W.C. Experimental determination of the activation parameters and stereoselectivities of the intramolecular Diels-Alder reactions of 1,3,8-Nonatriene, 1,3,9-Decatriene and 1,3,10-Undecatriene and transition state modeling with the Monte Carlo-Jumping Between Wells/molecular dynamics method J. Am. Chem. Soc., 1997, 119, 10255-10259
     
  25. Senderowitz, H.; Still, W.C. Anomeric free energy of D-mannose in water: A comparison of free energy perturbation, potential of mean force and MC(JBW)/SD simulations J. Phys. Chem. B, 1997, 101, 1409-1412
     
  26. Senderowitz, H.; Still, W.C. A quantum mechanically derived all atom force field for pyranose oligosaccharides. AMBER* parameters and free energy simulations J. Org. Chem., 1997, 62, 1427-1438
     
  27. Senderowitz, H.; Fuchs, B. Steric and stereoelectronic effects in saturated heterocycles. 1. Small molecular fragment constituents. Theory vs. experiment Journal of Molecular Structure (THEOCHEM), 1997, 395, 123-155
     
  28. Golender, L.; Senderowitz, H.; Fuchs, B. Relative stabilities and conformational ring inversion potential in heterodecalins decalin systems and stereoelectronic implications Journal of Molecular Structure (THEOCHEM), 1996, 370, 221-236
     
  29. Senderowitz, H.; Parish, C.; Still. W.C. Carbohydrates: United atom AMBER* parameterization of pyranoses and simulations yielding anomeric free energies J. Am. Chem. Soc., 1996, 118, 2078-2086
     
  30. Senderowitz, H.; Guarnieri, F.; Still, W.C. A smart Monte Carlo technique for free energy simulations of multiconformational molecules. Direct calculation of the conformational populations of organic molecules J. Am. Chem. Soc., 1995, 117, 8211-8219
     
  31. Senderowitz, H.; Linden, A.; Golender, L.; Abramson, S.; Fuchs, B. New supramolecular host system. 1. A structural and conformational study of the 1,3,5,7-Tetraoxadecalin core system Tetrahedron, 1994, 50, 9691-9706
     
  32. Senderowitz, H.; Golender, L.; Fuchs, B.  New supramolecular host system. 2. 1,3,5,7-Tetraoxadecalin, 1,2-Dimethoxymethane and the gauche effect reappraised. Theory vs. experiment Tetrahedron, 1994, 50, 9707-9728
     
  33. Senderowitz, H.; Aped, P.; Fuchs, B. computations of O-C-F and N-C-F systems: Ab initio calculations and a MM2 parameterization study. Theory vs. experiment Tetrahedron, 1993, 49, 3879-3898
     
  34. Senderowitz, H.; Aped, P.; Fuchs, B. Modified MM2 scheme for computation of O-C-N containing systems J. Comput. Chem., 1993, 14, 944-960
     
  35. Aped, P.; Fuchs, B.; Goldberg, I.; Senderowitz, H.; Tartakovsky, E.; Weiman, S. Structure and conformation of heterocycles. 21. Probing the anomeric effect in orthoesters. Structure, conformation and dynamic behavior of a unique Orthooxalate: 2,5,7,10,11,14-Hexaoxa[4.4.4]Propellane J. Am. Chem. Soc., 1992, 114, 5585-5590
     
  36. Senderowitz, H.; Aped, P.; Fuchs, B. Computation of N-C-N systems: Theory vs. experiment Tetrahedron, 1992, 48, 1131-1144
     
  37. Ben-Horin, N.; Senderowitz, H.; Kaldor, U.; Even, U.; Jortner, J. An electrostatic model for the energetics of large heteroclusters cations J. Phys. Chem., 1992, 96, 1569-1575
     
  38. Borremans, F.; Anteunis, M.; Aped, P.; Goldberg, I.; Senderowitz, H.; Tartakovsky, E.; Fuchs, B. Structure, conformation and stereoelectronics of 9,10-Annelated-1,4,5,8-tetraoxadecalins: A multidisciplinary probe Tetrahedron, 1991, 47, 5781-5796
     
  39. Senderowitz, H.; Aped, P.; Fuchs, B. Probing the anomeric effect in O-C-N systems: Theory vs. experiment. MO-ab initio calculations and a structural statistical analysis Helv. Chim. Acta, 1990, 73, 2113-2128
     
  40. Schleifer, L.; Senderowitz, H.; Aped, P.; Tartakovsky, E.; Fuchs, B. Diagnostic structural criteria for the anomeric effect in carbohydrate systems and inferences of general significance on their scope and limitations Carbohydrate Res., 1990, 206, 21-39
     
  41. Senderowitz, H.; Schleifer, L.; Aped, P.; Fuchs, B. Conformational energy and entropy differences of the t-butoxy group and implications in stereochemistry and stereoelectronics Tetrahedron Lett., 1989, 30, 6765-6768

 

Invited book chapters

  1. Senderowitz, H.; Rosenfeld R. Design of structural combinatorial libraries that mimic biological motif In “Combinatorial Library Design and Evaluation of Drug Discovery: Principles, Methods Software Tools and Applications” Ed. Arup K.G.  And Vellarkad N. V. Marcel Dekker, 2001, pp. 605-624
     
  2. Per editor request, this paper also appeared in Journal of Receptor and Signal Transduction Research, 2001, 21, 489-508
     
  3. Aped, P.; Senderowitz, H .Molecular mechanics calculations of amino, nitro and nitroso groups in "Supplement F2: The Chemistry of Amino, Nitroso, Nitro and related Groups” of "The Chemistry of Functional Groups", Ed. Saul Patai. John Wiley & Sons, 1996, pp 1-84

 

Patents

  1. W. Clark Still, Frank Guarnieri, Hanoch Senderowitz, US Patent 5740072 - Rapidly convergent method for Boltzmann-weighted ensemble generation in free energy simulations, filed 10/07/1994, publication date 25/04/1996, issued 14/04/1998
     
  2. Elias Dana, Avron Ann, Hanoch Senderowitz, PCT/IL01/01144 - Backbone cyclized inhibitors of heat shock proteins, filed 11/12/2001, publication date 20/06/2002
     
  3. Livnah Nurit, Yechezkel Tamar, Salitra Yosef, Perlmutter Boris, Ohne Onsat, Cohen Ilana,  Litman Pninit, Senderowitz Hanoch, PCT/IL2002/000618 – Protein kinase inhibitors comprising ATP mimetics conjugated to peptides or peptidomimetics, filed 25/07/2002, publication date 06/02/2003
     
  4. Oren Becker, Rosa Melendez, Yael Marantz, Anurag Sharadendu, Merav Fichman, Mercedes Lobera, Hanoch Senderowitz, Srinivasa Rao Cheruku, Silvia Noiman, Xiang Y. Yu, Sharon Shacham, Laurence Wu, Ashis Saha, Pini Orbach, Dale S. Dhanoa, PCT/US2006/002718 - Substituted arylamine compounds and methods of treatment, filed 25/01/2006, publication date 03/08/2006

 

INVITED TALKS

  1. Stereoelectronics in O-C-N systems I. Theory vs. experiment: MO-Ab initio calculations and a structural statistical analysis Presented at the 56th convention of the Israeli Chemical Society, February, 1991, Jerusalem, Israel
     
  2. Computations of N-C-N systems, Theory vs. experiment
    Presented at ESOR III, the 3rd European Symposium on Organic Reactivity, July 1991, Götenborg, Sweden 
     
  3. A smart Monte Carlo technique for free energy simulations of multiconformational molecules. Direct calculation of the conformational populations of organic molecules
    Presented at the 211th ACS Meeting, March 1996, New Orleans, USA
     
  4. Inhibition of protein-protein interactions through rational design of peptidomimetic libraries that mimic biological motifs
    Presented at the at the 2001 meeting of the Israeli society for bioinformatics and computational biology, June, 2001, Tel Aviv University, Tel Aviv, Israel
     
  5. Also presented at the 2nd congress of the Israel association for medicinal chemistry and drug development, March 2003, Israel
  6. Ki predictions for ligands docked into target proteins
    Presented at the 15th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modeling, September, 2004, Istanbul, Turkey
     
  7. QSPR models in lead discovery and lead optimization
    Presented at the 5th European Workshop on Drug Design, June 2005, Siena, Italy
     
  8. In silico predictions of ADME/t related properties
    Presented at the 70th meeting of the Israeli Chemical Society, February 2005, Tel Aviv, Israel
     
  9. In silico modeling of membrane proteins: Application to CFTR
    Presented at the 2005 NACFC meeting, October 2005, Baltimore, USA
     
  10. Also presented at the 2005 annual national Israeli CF conference, December 2005, Herzeliya, Israel and at the 2006 meeting of the Israeli society for bioinformatics and computational biology, October, 2006, Bar-Ilan University, Israel
     
  11. In silico drug discovery for CF-related targets
    Presented at the 2006 NACFC meeting, Denver, October 2006
     
  12. Also presented at the 2006 annual national Israeli CF conference, December 2006, Herzeliya, Israel
     
  13. In silico drug discovery: Applications to GPCRs and ion channels
    Presented at the Elsevier MDL 2007 European Users' Group Meeting, February 2007, Strasbourg, France
     
  14. In silico drug discovery: Methods and applications for CF-related targets
    Presented at the 6th European Workshop on Drug Design, June 2007, Siena, Italy
     
  15. Also presented at the 73rd meeting of the Israeli Chemical Society, February 2008, Jerusalem, Israel
     
  16. Modeling full length CFTR: From sequence to structure
    Presented at the 2007 NACFC meeting, October 2007, Anaheim, USA
     
  17. Also presented at the 2007 annual national Israeli CF conference, December 2007, Herzeliya, Israel
     
  18. DF508 CFTR: A target for computer-aided drug development
    Presented at the 2008 Cystic Fibrosis Foundation Williamsburg conference, June 2008, Williamsburg, USA
     
  19. Industrial-academic collaborations
    Presented at the Cystic Fibrosis Foundation 2008 Williamsburg conference, June 2008, Williamsburg, USA
     
  20. Computer Aided Drug Discovery in the Cystic Fibrosis Arena: From Sequence to the Lab
    Presented at the 2nd Joint Expert Meeting, Working Groups 1/2/3/4, COST Action CM0801, May 2010, Siena, Italy
     
  21. Computer Aided Drug Discovery: Methodologies, Challenges and Applications in the Cystic Fibrosis Arena
    Presented at the 1st iDDi Workshop in Negected and Orphan Diseases, May 2010, Siena, Italy
     
  22. Computer Aided Drug Design: Can QM Make a Difference?
    Presented at the Computational Chemistry Symposium, Lise Meitner Minerva Center, November 2010, Jerusalem, Israel
     
  23. Biasing Conformational Ensembles Towards Bioactive-Like Conformers for Ligand-Based Drug Design
    Presented at the 9th Conference of the Israel Association of Medicinal Chemistry, March 2011, Rehovot, Israel
     
  24. CFTR: Structure, Function, Genetics and Drugability
    Presented at the 8th European Workshop on Drug Design, May 2011, Siena, Italy
     
  25. CFTR: A Drugable Target for the Treatment of Cystic Fibrosis
    Presented at the 29th Cyprus-Camerino-Noordwijkerhout Trends in Drug Research Medicinal Chemistry EFMC Symposium, October 2011, Cyprus
     
  26. CFTR: A Drugable target for combating Cystic Fibrosis
    Presented at the 77th meeting of the Israeli Chemical Society, February 2012, Tel-Aviv, Israel
     
  27. Computer Aided Drug Design as a Single / Multiple Objective Optimization Problem
    Presented at the 1st Israeli Workshop on Multi Criteria Optimization and Decision Making, February 2012 Ort Braude College, Carmiel, Israel
     
  28. Computational Studies on the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
    Presented at the Structural Biology & Medicinal Chemistry WG1/WG3 meeting, COST Action CM0801, May 2012, Siena, Italy
     
  29. Focusing Conformational Ensembles on Bioactive Conformations
    Presented at the 3rd Strasbourg Summer School on Chemoinformatics, Strasbourg, France, 25-29 June 2012
     
  30. Computational Studies on CFTR
    Presented at the 4th annual meeting of Cost Action CN0801, September 2012, Crete, Greece
     
  31. Computational studies in search for CFTR modulators
    Presented at the Frontiers in Structural Biology of Membrane Proteins symposium, April, 2013, Center of for Structural Biology, University of Alabama at Birmingham, USA
     
  32. Insight into the structure, function and energetics of CFTR and its domains gained from atomic-level molecular simulations
    Presented at the 2013 ECFC Basic Science Conference, March, 2013, Malaga, Spain.
     
  33. What could be learnt on the structure, dynamics and energetics of the ABC transporter CFTR from atomistic simulations
    Presented at the 9th European Workshop on Drug Design, May 2013, Siena, Italy