ברנט-יצחקי

לפרטים על תואר ראשון ושני

למידע נוסף על לימודים אקדמיים בלבד השאירו פרטיכם ונחזור בהקדם

ראשי » ברנט-יצחקי
ד"ר ברנט-יצחקי זהר,
מרצה
  • בתיאום מראש

Curriculum Vitae
קורות חיים

Education

השכלה

  

  • 2001-2004, B.Sc. Computer science, Biology and Bioinformatics, The Hebrew University of Jerusalem     
  • 2005-2006, M.Sc. (direct track), Bioinformatics, Genomics and Microbiology, The Hebrew University of Jerusalem
  • 2006-2011, Ph.D, Bioiformatics, Genomics and Microbiology, The Hebrew University of Jerusalem, supervisor: prof. Hanah Margalit. Thesis: “Domain-domain Interactions as Mediators of Protein Interactions: Evolution, Hierarchy and Dynamics”
  • 2011-2013, post-doc, Bioinformatics and Immuno-genomics, Dr. Ido Amit’s lab. Weizmann Institute of Science
  • 2015-2016, post-doc (Mimshak program), Environment, Leadership, and Science consultant in the government, Tel-Aviv university and the Israeli Academy of Science and Humanities.

 

 

Work Experience

ניסיון עבודה

 

  • 2011-2015, Teacher and developer, MOH Biology Davidson Institute, Weizmann institute of science.           
  • 2011-2013, Bioinformatician, Rosetta Genomics.
  • 2015-2016, Bioinformatics team leader, Taliaz LTD.
  • 2015-2016, Scientific advisor for the head of public health services, The Ministry of Health.
  • 2016- present, Researcher at the Ministry of Health.
  • 2016- present, Faculty member and lecturer at Lev Academic Center.

 

Publications

פרסומים

 

  1. Itzhaki Z, Akiva E, Altuvia Y, Margalit H: Evolutionary conservation of domain-domain interactions. Genome Biol 2006 7(12):R125.
  2. Noverstern N, Itzhaki Z, Manor O, Friedman N, Kaminski N: A Functional and Regulatory Map of Asthma. Am J Respir Cell Mol Biol 2007 38(3):324-36.
  3. Akiva E, Itzhaki Z, Margalit H: Built-in Loops Allow Versatility in Domain-domain Interactions: Lessons from Self-interacting Domains. Proc. Natl. Acad. Sci. USA 2008 105(36):13292-7.  
  4. Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Willems P, Friedman N, Koopman W, Mitrani-Rosenbaum S: Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet. 2008 17(23):3663-74.  
  5. Reshef D, Itzhaki Z, Schueler-Furman O: Increased sequence conservation of domain repeats in prokaryotic proteins. Trends Genet. 2010 Sep;26(9):383-7.
  6.  Itzhaki Z, Akiva E, Margalit H: Preferential use of protein domain-pairs as interaction mediators: order and transitivity. Bioinformatics. 2010 Oct 15;26(20):2564-70.
  7. Itzhaki Z, Domain-domain interactions in herpesvirus-human interface. PLoS One 2011;6(7):e21724.
  8. Fleishman SJ, Whitehead TA, Itzhaki Z, et al: Community-wide assessment of protein-interface modeling suggests improvements to design methodology. J Mol Biol. 2011 Nov 25;414(2):289-302.
  9. Akiva E, Friedlander G, Itzhaki Z, Margalit H: A dynamic view of domain-motif interactions. PLoS Comput Biol. 2012 Jan;8(1):e1002341.
  10. Itzhaki Z, Margalit H: Reduced polymorphism in domains involved in protein-protein interactions. PLoS One 2012;7(4):e34503.
  11. Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14;47(5):810-22. 
  12. Mildner A, Chapnik E, Manor O, Yona S, Kim KW, Aychek T, Varol D, Beck G, Itzhaki Z, Feldmesser E, Amit I, Hornstein E, Jung S: Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood. 2013 Feb 7;121(6):1016-27.
  13. Blecher-Gonen R, Barnett-Itzhaki Z, Jaitin D, Amann-Zalcenstein D, Lara-Astiaso D, Amit I. High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states. Nat Protoc. 2013 Mar;8(3):539-54.
  14. Altboum Z, Steuerman Y, David E, Barnett-Itzhaki Z, Valadarsky L, Keren-Shaul H, Meningher T, Mendelson E, Mandelboim M, Gat-Viks I, Amit I. Digital cell quantification identifies global immune cell dynamics during influenza infection. Mol Syst Biol. 2014 Feb;10(2):720.
  15. Raza S, Barnett MW, Barnett-Itzhaki Z, Amit I, Hume DA, Freeman TC. Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. J Leukoc Biol. 2014 Aug;96(2):167-83.  
  16. Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science. 2014 Oct 3;346(6205):89-93.  
  17. Cohen M, Matcovitch O, David E, Barnett-Itzhaki Z, Keren-Shaul H, Blecher-Gonen R, Jaitin DA, Sica A, Amit I, Schwartz M. Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J. 2014  33(24):2906-21. pii: e201489293.
  18. Bornstein C, Winter D, Barnett-Itzhaki Z, David E, Kadri S, Garber M, Amit I. A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States. Mol Cell. 2014
  19. Barzilai S, Blecher-Gonen R, Barnett-Itzhaki Z, Zauberman A, Lebel-Haziv Y, Amit I, Alon R. M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol. 2016. 99(6):1045-55.
  20. Barnett-Itzhaki Z, Berman T, Grotto I, Schwartzberg E. Household medical waste disposal policy in Israel. Isr J Health Policy Res. 2016. 10;5:48. eCollection 2016.
  21. Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, Shachar I. CD74 is a novel transcription regulator. Proc Natl Acad Sci U S A. 2017 ;114(3):562-567.
  22. Mildner A, Chapnik E, Varol D, Aychek T, Lampl N, Rivkin N, Bringmann A, Paul F, Boura-Halfon S, Hayoun YS, Barnett-Itzhaki Z, Amit I, Hornstein E, Jung S. MicroRNA-142 controls thymocyte proliferation. Eur J Immunol. 2017. doi: 10.1002/eji.201746987.

Patents

פטנטים

 

Mirna expression signature in the classification of thyroid tumors (WO 2015175660 A1), Rosetta Genomics.

 

     

Grants and awards

מענקים ופרסים

       

      

       2012, Abisch-frenkel Grant

 

     

Additional academic activity

פעילות אקדמית נוספת

        

         Journal refereeing:

1. Reviewer for the journal PLoS computational biology (2012).

2. Reviewer for the journal IEEE/ACM transactions on computational biology and bioinformatics (2011).

3. Reviewer for journal Nucleic Acid Research (2010)

4. Reviewer for ISMB 2009 conferences.

5. Reviewer for the journal Bioinformatics (2007-2011).

 

         Conference lectures:

1. A novel mechanism for super-inducibility of inflammatory cytokines expression. Helmsley workshop. Rehovot, 2012.

2. The Hierarchy of Domain Pairs as Protein-interaction Mediators. System biology: Networks. Cold Spring Harbor, USA, 2009.

3. The Hierarchy of Domain Pairs as Protein-interaction Mediators. The annual Sudarsky Center for Computational Biology conference. Jerusalem, 2008.

4. Domain-domain interactions are evolutionary conserved. The 15th Annual international conference on Intelligent Systems for Molecular Biology. Vienna, 2007.

5. Household medical waste policy in Israel. ISEES' annual conference. Tel-Aviv 2016.

 

         Conference organization:          

Organizing the conference: “Antibiotic resistance in wastewater” for the academy, the industry and for government ministries. Tel Aviv, 2016.